Search found 29 matches

by GrumpyOldResearcher
Sat Apr 18, 2026 11:00 am
Forum: General Discussion
Topic: Hexarelin deep dive - 6 week log + what nobody tells you about the hunger and cortisol piece
Replies: 17
Views: 23538

Re: Hexarelin deep dive - 6 week log + what nobody tells you about the hunger and cortisol piece

<r><QUOTE author="xX_SleepQueenXx"><s>[quote=xX_SleepQueenXx]</s>your correction about how cardiac effects are "independent of GH release" is... cool I guess?? what am I supposed to DO with that lol<e>[/quote]</e></QUOTE>

You're supposed to not design a protocol assuming two separate effects are ...
by GrumpyOldResearcher
Thu Apr 16, 2026 11:00 am
Forum: General Discussion
Topic: Hexarelin deep dive - 6 week log + what nobody tells you about the hunger and cortisol piece
Replies: 17
Views: 23538

Re: Hexarelin deep dive - 6 week log + what nobody tells you about the hunger and cortisol piece

<r><QUOTE author="biohack_bella_87"><s>[quote=biohack_bella_87]</s>I kept hearing from various corners of the community (shoutout to the Nootopia guys and some of the older threads on Longecity that I fell down a rabbit hole on) that the cardioprotective angle was underexplored.<e>[/quote]</e ...
by GrumpyOldResearcher
Mon Apr 13, 2026 11:45 am
Forum: General Discussion
Topic: Differential GLP-1 Receptor Downregulation Kinetics Between Continuous vs. Intermittent Semaglutide Dosing Protocols - Has Anyone Investigated This?
Replies: 14
Views: 56276

Re: Differential GLP-1 Receptor Downregulation Kinetics Between Continuous vs. Intermittent Semaglutide Dosing Protocols - Has Anyone Investigated This?

<r><QUOTE author="IronGutPeptideBro"><s>[quote=IronGutPeptideBro]</s>is there a meaningful MINIMUM that gets you like 60-70% of the way there?<e>[/quote]</e></QUOTE>

Nobody knows. That is the honest answer. GPCR resensitization kinetics are not linear and receptor density restoration is not a ...
by GrumpyOldResearcher
Mon Apr 13, 2026 11:00 am
Forum: General Discussion
Topic: Observations on PT-141 (Bremelanotide) Administration: Unexpected Autonomic Responses and Dosing Considerations
Replies: 5
Views: 23124

Re: Observations on PT-141 (Bremelanotide) Administration: Unexpected Autonomic Responses and Dosing Considerations

<r><QUOTE author="T_Ortega_Lifts"><s>[quote=T_Ortega_Lifts]</s>technically MC4R agonism does have some documented appetite-suppressing and metabolic effects - that's actually part of the melanocortin system's role<e>[/quote]</e></QUOTE>

This is correct and worth emphasizing. The melanocortin system ...
by GrumpyOldResearcher
Sun Apr 12, 2026 11:45 am
Forum: General Discussion
Topic: Observations on PT-141 (Bremelanotide) Administration: Unexpected Autonomic Responses and Dosing Considerations
Replies: 5
Views: 23124

Re: Observations on PT-141 (Bremelanotide) Administration: Unexpected Autonomic Responses and Dosing Considerations

<r><QUOTE author="xX_SleepQueenXx"><s>[quote=xX_SleepQueenXx]</s>wait wait wait. you were stacking PT-141 WITH ipamorelin/cjc during a cut?? like for weight loss purposes??<e>[/quote]</e></QUOTE>

He wasn't running it for the cut. He was just running it at the same time. People do have lives outside ...
by GrumpyOldResearcher
Fri Apr 10, 2026 11:00 am
Forum: General Discussion
Topic: My first time looking into peptides and I'm completely overwhelmed - where did you all actually start?
Replies: 9
Views: 64639

Re: My first time looking into peptides and I'm completely overwhelmed - where did you all actually start?

<r><QUOTE author="biohack_bella_87"><s>[quote=biohack_bella_87]</s>A lot of people in the biohacking space, and I'm talking people like the guests on Huberman's podcast who discuss peptide adjacent topics, keep coming back to it as like the foundational healing compound.<e>[/quote]</e></QUOTE>

I've ...
by GrumpyOldResearcher
Wed Apr 08, 2026 11:45 am
Forum: General Discussion
Topic: Hexarelin water retention - not a bug, it's a feature, stop whining about it
Replies: 1
Views: 12593

Hexarelin water retention - not a bug, it's a feature, stop whining about it

<t>Ran hexarelin at 100mcg twice daily for 6 weeks. Here's what actually happened.<br/>
<br/>
Week 1-2: nothing dramatic. Some hunger increase, expected. Slight water retention starting around day 10.<br/>
<br/>
Week 3-4: strength numbers moved. Not imagining it. Pull movement PRs went up, recovery ...
by GrumpyOldResearcher
Thu Apr 02, 2026 11:45 am
Forum: General Discussion
Topic: LL-37 experience - 6 weeks in and I have some thoughts (the good and the messy)
Replies: 5
Views: 41117

Re: LL-37 experience - 6 weeks in and I have some thoughts (the good and the messy)

<r><QUOTE author="gainz_peptide_bro"><s>[quote=gainz_peptide_bro]</s>might have to look more into LL-37 for real though, the immune angle is interesting. im mostly a GH peptide guy but ive been dealing with some annoying inflammation stuff that wont quit so im cutious<e>[/quote]</e></QUOTE>

Worth ...
by GrumpyOldResearcher
Wed Apr 01, 2026 11:45 am
Forum: General Discussion
Topic: TB-500 vs Thymosin Beta-4 - are these actually the same thing or am i missing something??
Replies: 10
Views: 61404

Re: TB-500 vs Thymosin Beta-4 - are these actually the same thing or am i missing something??

<r><QUOTE author="biohack_bella_87"><s>[quote=biohack_bella_87]</s>Dave Asprey has talked about the broader bioactivity distinctions on Bulletproof Radio, Andrew Huberman's discussed peptide mechanisms at length, the Ben Greenfield sphere has covered this extensively. Are ALL of those conversations ...
by GrumpyOldResearcher
Tue Mar 31, 2026 12:45 pm
Forum: General Discussion
Topic: TB-500 vs Thymosin Beta-4 - are these actually the same thing or am i missing something??
Replies: 10
Views: 61404

Re: TB-500 vs Thymosin Beta-4 - are these actually the same thing or am i missing something??

gainz_peptide_bro wrote:i frontloaded at 2mg twice a week which is lower than what some guys do but it worked for me
What was the total duration of your run? And did you taper down after the loading phase or just stop cold?